Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca 2+ and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagy

Osteopenia and osteoporosis are among the most common metabolic bone diseases and represent major public health problems, with sufferers having an increased fracture risk. Diabetes is one of the most common diseases contributing to osteopenia and osteoporosis. However, the mechanisms underlying diabetes-induced osteopenia and osteoporosis remain unclear. Bone reconstruction, including bone formation and absorption, is a dynamic process. Large-conductance Ca