Optimization and development of a green high performance liquid chromatography for determination of 8 anti-epileptic drugs and 2 active metabolites in human serum assessed using AGREE, AGREEprep, GAPI and BAGI

Pharmacological treatment with antiepileptic drugs (AEDs) remains the primary choice for most patients with epilepsy, while therapeutic drug monitoring is an important strategy to ensure the efficacy and safety of AEDs.