Reprogramming Komagataella phaffii for a Robust Chassis toward Efficient De Novo Biosynthesis of (−)-α-Bisabolol

bisabolol-producing strain, KB-30. Finally, the highly efficient production of (-)-α-bisabolol was achieved in a 5 L fed-batch fermenter, giving a titer of 32.8 g/L and a space-time yield of 283 mg/L/h. This work represents the highest production of (-)-α-bisabolol to date and provides new insights for efficient terpenoid biosynthesis.