医学
肌萎缩侧索硬化
星形胶质增生
病理
单胺氧化酶B
失智症
病理生理学
痴呆
单胺氧化酶
疾病
内科学
中枢神经系统
生物化学
酶
化学
作者
Mana Higashihara,Kenji Ishibashi,Aya M. Tokumaru,Atsushi Iwata,Kenji Ishii
出处
期刊:Clinical Nuclear Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2021-06-11
卷期号:46 (12): e582-e583
被引量:11
标识
DOI:10.1097/rlu.0000000000003755
摘要
Abstract Two patients with different amyotrophic lateral sclerosis (ALS) phenotypes underwent 18 F-THK5351 PET to visualize lesions undergoing astrogliosis by measuring monoamine oxidase B activity. Patient 1 was a 57-year-old man with flail leg syndrome. Elevated uptake was observed inside the motor cortex, corresponding to the leg area in a cortical homunculus. Patient 2 was a 64-year-old man with ALS-frontotemporal dementia semantic variant. Elevated uptake was observed around the left anterior temporal lobe. Both core lesions were consistent with their respective neurological features. Hence, 18 F-THK5351 PET is a useful technique to assess ALS pathophysiology by visualizing the core lesions.
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