H2O2 Self-Supplying and GSH-Depleting Nanoplatform for Chemodynamic Therapy Synergetic Photothermal/Chemotherapy

Chemodynamic therapy (CDT) that utilizes Fenton-type reactions to convert endogenous hydrogen peroxide (H 2 O 2 ) into hydroxyl radicals ( • OH) is a promising strategy in anticancer treatment, but the overexpression of glutathione (GSH) and limited endogenous H 2 O 2 make the efficiency of CDT unsatisfactory. Here, an intelligent nanoplatform CuO 2 @mPDA/DOX-HA (CPPDH), which induced the depletion of GSH and the self-supply of H 2 O 2, was proposed. When CPPDH entered tumor cells through the targeting effect of hyaluronic acid (HA), a release of Cu 2+ and produced H 2 O 2 were triggered by the acidic environment of lysosomes. Then, the Cu 2+ was reduced by GSH to Cu +, and the Cu + catalyzed H 2 O 2 to produce • OH. The generation of • OH could be distinctly enhanced by the GSH depletion and H 2 O 2 self-sufficiency. Besides, an outstanding photothermal therapy (PTT) effect could be stimulated by NIR irradiation on mesoporous polydopamine (mPDA). Meanwhile, mPDA was an excellent photoacoustic reagent, which could monitor the delivery of nanocomposite materials through photoacoustic (PA) imaging. Moreover, the successful delivery of doxorubicin (DOX) realized the integration of chemotherapy, PTT, and CDT. This strategy could solve the problem of insufficient CDT efficacy caused by the limited H 2 O 2 and overexpression of GSH. This multifunctional nanoplatform may open a broad path for self-boosting CDT and synergistic therapy.