胡椒粉
细胞毒性T细胞
程序性细胞死亡
生物
细胞凋亡
细胞毒性
化学
细胞培养
传统医学
生物化学
医学
食品科学
遗传学
体外
作者
Micael Rodrigues Cunha,Maurício Temotheo Tavares,Thaís Fernandes,Roberto Parise-Filho
出处
期刊:Molecules
[MDPI AG]
日期:2021-03-10
卷期号:26 (6): 1521-1521
被引量:5
标识
DOI:10.3390/molecules26061521
摘要
Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.
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