Ligand‐ and Base‐Free Cu‐Catalyzed C−N Coupling of Aminoquinolines with Boronic Acids

Abstract A ligand‐ and base‐free Cu‐catalyzed protocol for the synthesis of N ‐arylquinolin‐8‐amine and N ‐arylquinolin‐3‐amine derivatives has been developed. A wide range of N ‐aryl heterocycles were synthesized in moderate to good yields under the mild condition of 10 mol% Cu(OAc) 2 in 3 mL methanol at room temperature in presence of air.