化学
区域选择性
羟醛缩合
立体选择性
羟醛反应
基质(水族馆)
表面改性
天然产物
组合化学
冷凝
有机化学
立体化学
催化作用
地质学
物理化学
物理
海洋学
热力学
作者
Ramakrishna Samala,Manas K. Basu,K. Mukkanti
标识
DOI:10.1016/j.tetlet.2021.153574
摘要
Herein, we disclose our efforts directed toward the synthesis of the kavalactone-based natural product penstyrylpyrone and other related 4-OMe-2-pyrones possessing diverse substituents at the 3-, 5-, and 7-positions. Further, a facile approach to access 6-styrylpyrones via the KHMDS-mediated regioselective aldol condensation of 2-pyrones is described with moderate substrate scope and good to high yields (58–80%). The utility of this methodology was exemplified by the stereoselective construction of desmethoxyyangonin, asnipyrone A, and asnipyrone B.
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