Treatment of Uterine Fibroid Symptoms With Relugolix Combination Therapy

(Abstracted from N Engl J Med 2021;384:630–642) Approximately 25% of women with uterine fibroids experience symptoms, most commonly heavy menstrual bleeding (HMB) or fibroid-associated pain. Long-acting gonadotropin-releasing hormone (GnRH) agonists are effective for the medical management of uterine fibroids, but their duration of use is limited by hypoestrogenic sequelae.