冰片
化学
色谱法
质谱法
药代动力学
气相色谱-质谱法
胶囊
樟脑
气相色谱法
药理学
中医药
医学
有机化学
病理
替代医学
生物
植物
作者
Jingqing Mu,Xun Gao,Qing Li,Xiaomei Yang,Wenling Yang,Xin Sun,Kaishun Bi,Huifen Zhang
标识
DOI:10.1002/jssc.201700500
摘要
Guanxin Shutong Capsule, an effective traditional Chinese medicine, is widely used for coronary heart disease clinically. Volatile components are one of its important bioactive constituents. To better understand the material basis for the therapeutic effects, the components of Guanxin Shutong Capsule absorbed into the blood and their metabolites were identified based on gas chromatography with mass spectrometry coupled with vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction. As a result, three prototypes and 15 metabolites were identified or tentatively characterized in rat plasma. Subsequently, a pharmacokinetic study was carried out to monitor the concentrations of the main bioactive constituents and metabolites (isoborneol, borneol, eugenol, and camphor) by gas chromatography with mass spectrometry in rat plasma following oral administration of single herb extract and different combinations of herbs in this prescription. Compared to other groups, a statistically significant difference of the pharmacokinetic properties was obtained when the total complex prescription was administered, indicating possible drug–drug interactions among the complex ingredients of Guanxin Shutong Capsule. These findings provided an experimental basis concerning the clinical application and medicinal efficacy of Guanxin Shutong Capsule in the treatment of coronary heart disease.
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