Amino-bisphosphonates, γδT cells, and their roles in Rheumatoid Arthritis

We thank Dr Rossini and colleagues1 for their interesting comments on our manuscript.2 Aminobisphosphonates (N-BPs), the analogue of isopentenyl pyrophosphate, promote the activation and proliferation of peripheral γδ T cells, specifically Vγ9/Vδ2 T cells,3 which are the cells we showed that play an important role in the pathogenesis of rheumatoid arthritis (RA).2 We fully agree that γδ T cells are one of the major factors that may contribute to N-BPs-related acute phase response …