Selenium‐Based Nanozyme as Biomimetic Antioxidant Machinery

Abstract A self‐assembly nanocomposite was designed to mimic intracellular enzymatic and non‐enzymatic antioxidants‐constituted antioxidant defense machinery. In this work, selenium nanocomponent served as one model to mimic antioxidant enzyme, whereas polydopamine was able to mimic non‐enzymatic antioxidant biomolecule in living systems. With the excellent glutathione peroxidase‐mimic capacity of selenium and the reducibility of polydopamine, this Se@pDA nanozyme could achieve synergetic antioxidative efficiency to protect cellular components against oxidative damage. The pneumonia model of mice further proved the potential of our nanocomposites for anti‐inflammation therapy.