自愈水凝胶
组织工程
再生(生物学)
材料科学
聚合物
人造皮肤
生物医学工程
皮肤修复
纳米技术
再生医学
干细胞
高分子化学
伤口愈合
复合材料
外科
细胞生物学
生物
医学
工程类
作者
Kwang-Hun Jeong,Duckshin Park,Young-Chul Lee
标识
DOI:10.1007/s10965-017-1278-4
摘要
Polymer hydrogels consist of a three-dimensional (3D) structure with cross-linked networks rich in a huge amount of water through hydrogen-bonding interactions, making them highly hydrophilic. Due to their impressive hydrophilic characteristics and cell non-cytotoxicity, polymer hydrogels are useful tissue engineering tools for the organization of cells and tissues and organ regeneration. Many biomedical engineers and researchers have recently begun to utilize polymer hydrogels as tissue or cell culture environments and as scaffolds for the stable growth of organs in tissue engineering and regeneration medicine. This paper focuses on skin regeneration in polymer hydrogels where skin is a means of protecting the body from infection or physical or chemical damage. Generally, skin tissue that has incurred minor damage or wounds can regenerate and heal in a relatively short time, while severe injuries may require transplantation or artificial skin. For those purposes, skin culturing in an in vitro environment is essential, and the environment produced using polymer hydrogel scaffolds needs to be both similar to the real environment and safe for skin cell growth. This paper reviews post-2000 skin regeneration research in the field of tissue engineering, focusing specifically on polymer hydrogels; it also discusses some of the central perspectives and key issues.
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