灰质
白质
基于体素的形态计量学
老化
脑岛
内嗅皮质
扁桃形结构
扣带皮质
体素
心理学
脑形态计量学
磁共振成像
神经科学
人脑
医学
皮质(解剖学)
解剖
生物
海马体
中枢神经系统
内科学
放射科
作者
Catriona D. Good,Ingrid S. Johnsrude,John Ashburner,Richard N. Henson,Karl J. Friston,R. S. J. Frackowiak
出处
期刊:NeuroImage
[Elsevier]
日期:2001-07-01
卷期号:14 (1): 21-36
被引量:4232
标识
DOI:10.1006/nimg.2001.0786
摘要
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans.
科研通智能强力驱动
Strongly Powered by AbleSci AI