信号识别粒子
内质网
信号识别粒子受体
细胞生物学
转运蛋白
分泌途径
蛋白质靶向
膜蛋白
分泌蛋白
功能(生物学)
膜
化学
信号肽
生物
生物化学
肽序列
分泌物
基因
高尔基体
作者
Joen Luirink,Irmgard Sinning
标识
DOI:10.1016/j.bbamcr.2004.03.013
摘要
The signal recognition particle (SRP) and its membrane-bound receptor (SR) deliver membrane proteins and secretory proteins to the translocation channel in the plasma membrane (or the endoplasmic reticulum). The general outline of the SRP pathway is conserved in all three kingdoms of life. During the past decade, structure determination together with functional studies has brought our understanding of the SRP-mediated protein transport to an almost molecular level. An impressive amount of new information especially on the prokaryotic SRP is integrated into the current picture of the SRP pathway.
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