Regulation of Bone Formation

DURING the past two decades our ideas about the regulation of bone formation have been expanded by new findings at the molecular, cellular, and tissue level. At the molecular level we have learned how collagen, the major component of bone matrix, is synthesized, and we have identified several noncollagen proteins in bone. At the cellular level we have learned more about the hormonal control of the osteoblasts that synthesize bone matrix. At the tissue level the concept of coupling between osteoclastic bone resorption and osteoblastic bone formation in bone remodeling has provided a new way to describe the relation between . . .