小型化
光纤
毫秒
材料科学
光纤传感器
纤维
荧光
光电子学
纳米技术
光学
天文
物理
复合材料
作者
Weihong Tan,Zhong-You Shi,Steve Smith,Duane Birnbaum,Raoul Kopelman
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1992-10-30
卷期号:258 (5083): 778-781
被引量:256
标识
DOI:10.1126/science.1439785
摘要
A thousandfold miniaturization of immobilized optical fiber sensors, a millionfold or more sample reduction, and at least a hundredfold shorter response time, all simultaneously, were achieved by combining nanofabricated optical fiber tips with near-field photopolymerization. Specifically, pH optical fiber sensors were prepared with internal calibration, making use of the differences in both fluorescence and absorption of the acidic and basic dye species. The submicrometer sensors have excellent detection limits, as well as photostability, reversibility, and millisecond response times. Successful applications include intracellular and intraembryonic measurements. Potential applications include spatially and temporally resolved chemical analysis and kinetics inside single biological cells and their substructures.
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