2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate

All articles of this category Although benzyne ( 4 ) has been widely used in organic synthesis, there are relatively few ways of generating it under mild conditions from readily available chemicals. Subjecting 2-(trimethylsilyl)phenyl trifluoromethanesulfonate ( 3 ) to fluoride-induced 1,2-elimination generates benzyne conveniently at room temperature without the use of strong bases or oxidants.