Advances in Pyrazole as an Active Fragment for Herbicide Discovery

Pyrazole and its derivatives have considerably advanced the discovery and development of innovative agrochemicals owing to their unique chemical structures and exceptional biological activities. Numerous pesticides featuring the pyrazole fragment as a key structural element have been extensively identified. This review systematically summarized pyrazole as a prevalent active fragment in the exploration of novel herbicides, focusing on its structural properties. Moreover, this work has primarily analyzed the herbicidal activity of pyrazole compounds, discussed the structure-activity relationships, and explored structure-based drug design strategies and mechanisms of action. The objective is to inspire new approaches for herbicide discovery.