Open-Source Light Calibration System for Hyperbilirubinemia Phototherapy Treatments

Abstract Neonatal jaundice or neonatal hyperbilirubinemia is a common medical condition impacting newborns and pathological jaundice if left untreated leads to neurological encephalopathy and/or death. The majority of pathological jaundice cases occur in low and middle- income countries (LMIC). Phototherapy has been determined to be the safest and most effective treatment for jaundice. Although inexpensive light emitting diodes are available on the market, commercial phototherapy devices are expensive (∼US$2,000), which creates a barrier to access for these devices in LMIC. Efforts to construct cost effective phototherapy units have been implemented in the past but need a method to validate the intensity and wavelength of light received by the infant at a distance away from the source. To enable low-cost phototherapy units to be used clinically, this study provides an open source, low- cost, distributed manufacturing approach to create a light sensor to calibrate phototherapy units. This instrument is a necessary component of any open source phototherapy treatment used in a clinical setting. This novel instrument was validated by comparing its irradiance and wavelength reading to the commercially calibrated Ocean Insight UV-VIS spectrometer under varying lighting conditions including that of the existing Datex-Ohmeda Giraffe Spot PT Lite phototherapy equipment accessible through Victoria Children’s Hospital Neonatal Care Ward in London, Ontario and Kiambu County Hospital in Kenya. The results of this study have demonstrated that for under US$150, a phototherapy calibration device can be constructed capable of measuring up to 200uW/cm 2 /nm with an accuracy of 98.6% and detect the peak wavelength within +/- 12.5 nm. It can be concluded that 3D printed open- source irradiance meters are a viable option for calibrating phototherapy units in LMIC to treat hyperbilirubinemia.