Organ‐Targeted and Organelle‐Targeted Liposome Gene Vector Construction

Abstract The objective of this study is to systematically evaluate the advantages and disadvantages of liposomes as gene delivery agents, highlighting the importance of targeting in improving the efficiency and specificity of gene delivery. Systematic examination of these factors results in a robust theoretical underpinning and practical directives for the development of high‐performance liposome vectors designed for targeted organ and organelle delivery. The research findings are poised to substantially bolster the evolution and practical deployment of gene therapy across various disease treatments. The research findings are poised to substantially bolster the evolution and practical deployment of gene therapy across various disease treatments. Comprehensive details on the production methods and regulatory aspects of targeted liposomes are presented, covering major organs like the liver, kidney, spleen, and lung, as well as pivotal organelles such as the nucleus, mitochondria, and lysosome. To target liposomes precisely, surface modification, composition and structure optimization, and physical variable control are utilized. The method demonstrates considerable therapeutic efficacy in gene editing, metabolic disorder treatment, and lysosomal storage disease management. Innovative strategies for optimizing liposome delivery systems are delineated in this study, emphasizing their revolutionary role in gene therapy.