Diastereoselective and enantioselective construction of 1,4-nonadjacent alkyne-tethered products through Cu I -promoted deprotonation and addition of terminal alkynes

An asymmetric alkynylation reaction of prochiral terminal diynes is developed through a tandem Cu I -mediated desymmetrising deprotonation and enantioselective addition process, furnishing products with alkyne-tethered 1,4-central chirality.