Design, docking optimization, and evaluation of biotin-PEG4-1,8-naphthalimide as potent and safety antitumor agent with dual targeting of ferroptosis and DNA

A set of biotin-polyethylene glycol (PEG)-naphthalimide derivatives 4a–4h with dual targeting of ferroptosis and DNA were designed and optimized using docking simulation as antitumor agents.