硫酸乙酰肝素
细胞外基质
血管生成
癌细胞
化学
肽
细胞生长
佩莱肯
硫酸化
成纤维细胞生长因子
细胞生物学
细胞外
生物物理学
生长因子
生物化学
细胞
癌症
癌症研究
生物
受体
遗传学
作者
Jiaqi Song,Liang Shao,Hongwen Yu,Caiting Meng,Guanying Li
标识
DOI:10.1021/acs.biomac.4c00168
摘要
Heparan sulfate proteoglycans (HSPGs) play a crucial role in regulating cancer growth and migration by mediating interactions with growth factors. In this study, we developed a self-assembling peptide (S1) containing a sulfate group to simulate the contiguous sulfated regions (S-domains) in heparan sulfate for growth factor binding, aiming to sequester growth factors like VEGF. Spectral and structural studies as well as simulation studies suggested that S1 self-assembled into nanostructures similar to the heparan sulfate chains and effectively bound to VEGF. On cancer cell surfaces, S1 self-assemblies sequestered VEGF, leading to a reduction in VEGF levels in the medium, consequently inhibiting cancer cell growth, invasion, and angiogenesis. This study highlights the potential of self-assembling peptides to emulate extracellular matrix functions, offering insights for future cancer therapeutic strategies.
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