Magnetically driven nanorobots based on peptides nanodots with tunable photoluminescence for rapid scavenging reactive α-dicarbonyl species and effective blocking of advanced glycation end products

The present work constructed magnetically driven nanorobots by conjugating the photoluminescent β-alanine-histidine (β-AH) nanodots to superparamagnetic nanoparticles (SPNPs) for simultaneously sensitive determination and fast trapping RDS in food processing, achieving efficient regulation of advanced glycation end products (AGEs) risk. Bio-derivative β-AH nanodots with orderly self-assembly nanostructure and tunable photoluminescent properties served as both biorecognition elements to effectively bind and scavenge the reactive α-dicarbonyl species (RDS), as well as the indicator with sensitive fluorescence response in the food matrix. The magnetically driven nanorobots with excellent biosafety of endogenous dipeptides displayed a high binding capacity of 80.12 mg g-1 with ultrafast equilibrium time. Furthermore, the magnetically driven nanorobots achieved rapid removal of the RDS with the manipulation of the external magnetic field, which enabled intercepting AGEs generation without byproducts residual as well as ease-of-operation. This work provided a promising strategy with biosafety and versatility for both accurate determination and efficient removal of hazards.