生物
长寿
表型
抛物线性
抗体
利基
细胞生物学
人口
免疫学
蛋白质周转
持久性(不连续性)
遗传学
基因
蛋白质生物合成
人口学
岩土工程
社会学
工程类
生态学
作者
Marcus James Robinson,Zhoujie Ding,Mark R. Dowling,Danika L. Hill,Rosela H. Webster,Craig McKenzie,Catherine Pitt,Kristy O’Donnell,Jesse Mulder,Erica Brodie,Philip D. Hodgkin,Nick C. Wong,Isaak Quast,David M. Tarlinton
标识
DOI:10.1016/j.immuni.2023.04.015
摘要
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and persistence using a genetic reporter to time-stamp ASCs. This approach revealed ASC lifespans as heterogeneous and falling on a continuum, with only a small fraction surviving for >60 days. ASC longevity past 60 days was independent of isotype but correlated with a phenotype that developed progressively and ultimately associated with an underlying "long-lived" ASC (LL ASC)-enriched transcriptional program. While some of the differences between LL ASCs and other ASCs appeared to be acquired with age, other features were shared with some younger ASCs, such as high CD138 and CD93. Turnover was unaffected by altered ASC production, arguing against competition for niches as a major driver of turnover. Thus, ASC turnover is set by intrinsic lifespan limits, with steady-state population dynamics governed by niche vacancy rather than displacement.
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