肠道菌群
免疫系统
生物
免疫学
肠-脑轴
肺
微生物学
医学
内科学
作者
Silu Ni,Xin Yuan,Qihang Cao,Yiming Chen,Xingyu Peng,Jingyi Lin,Yanyan Li,Wentao Ma,Shan Gao,Dekun Chen
标识
DOI:10.1016/j.micpath.2023.106311
摘要
The community of microorganisms known as gut microbiota that lives in the intestine confers significant health benefits on its host, primarily in the form of immunological homeostasis regulation. Gut microbiota not only can shape immune responses in the gut but also in other organs. This review focus on the gut-lung axis. Aberrant gut microbiota development is associated with greater lung disease susceptibility and respiratory disease induced by a variety of pathogenic bacteria. They are known to cause changes in gut microbiota. Recent research has found that immune cells in the intestine migrate to distant lung to exert anti-infective effects. Moreover, evidence indicates that the gut microbiota and their metabolites influence intestinal immune cells. Therefore, we suspect that intestine-derived immune cells may play a significant role against pulmonary pathogenic infections by receiving instructions from gut microbiota.
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