催化作用
芳基
盐(化学)
镍
胺化
组合化学
化学
氨
小学(天文学)
配体(生物化学)
有机化学
生物化学
烷基
物理
受体
天文
作者
Geyang Song,Jiuzhou Song,Qi Li,Ding-Zhan Nong,Jianfei Dong,Gang Li,Juan Fan,Chao Wang,Jianliang Xiao,Xue Duan
标识
DOI:10.1002/anie.202314355
摘要
Cheap, stable and easy-to-handle Werner ammine salts have been known for more than a century; but they have been rarely used in organic synthesis. Herein, we report that the Werner hexammine complex [Ni(NH3 )6 ]Cl2 can be used as both a nitrogen and a catalytic nickel source that allow for the efficient amination of aryl chlorides in the presence of a catalytic amount of bipyridine ligand under the irradiation of 390-395 nm light without the need of any additional catalysts. More than 80 aryl chlorides, including more than 20 drug molecules, were aminated, demonstrating the practicality and generality of this method in synthetic chemistry. A slow NH3 release mechanism is in operation, obviating the problem of catalyst poisoning. Still interestingly, we show that the Werner salt can be easily recovered and reused, solving the problem of difficult recovery of transition metal nickel catalysts. The protocol thus provides an efficient new strategy for the synthesis of primary aryl amines.
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