上皮内淋巴细胞
生物
表观遗传学
转录组
舱室(船)
福克斯O1
固有层
转录因子
背景(考古学)
细胞生物学
CD8型
T细胞
免疫学
遗传学
上皮
免疫系统
基因
基因表达
DNA甲基化
古生物学
海洋学
地质学
作者
Paul Wei‐Che Hsu,Eunice J. Choi,William H. Wong,Yun Hsuan Lin,Sara A. Vandenburgh,Yi Chia Liu,Priscilla Yao,Cynthia S. Indralingam,G Yeo,Elina I. Zúñiga,Ananda W. Goldrath,Wei Wang,John T. Chang
出处
期刊:Science immunology
[American Association for the Advancement of Science]
日期:2025-04-11
卷期号:10 (106): eadn1894-eadn1894
被引量:3
标识
DOI:10.1126/sciimmunol.adn1894
摘要
Tissue-resident memory CD8 T (TRM) cells serve as a front-line defense against microbial pathogens in barrier and mucosal tissues. Accurately predicting the roles of tissue-specific transcription factors (TFs) that regulate TRM biology remains a challenge. Here, by applying integrated transcriptomic and epigenomic analyses, we have identified an unexpected role for forkhead box O1 (Foxo1), a TF previously known to regulate circulating memory T cells, in intestinal TRM biology. Foxo1 repressed the maintenance of early small intestinal intraepithelial TRM cells in contrast with its actions in sustaining TRM cells from small intestinal lamina propria and colon and contrary to its broader role in promoting intestinal TRM cell formation. These findings highlight the emerging concept that the transcriptional regulation of TRM cells may be more complex and nuanced than previously appreciated and underscore the utility of integrated transcriptomic and epigenomic analyses in reconstructing TF-regulatory networks.
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