医学
回顾性队列研究
预测值
膜性肾病
抗体
内科学
免疫学
肾小球肾炎
肾
作者
Kezhi Zhou,Juntuo Zhou,Le-Ting Zhou,Jie Xue,Bin Liu,Zhijian Zhang,Xiran Zhang,Ting Cai,Sijia Shao,Biao Huang,Yi Zhang,Zhigang Hu,Liang Wang,Xiaobin Liu
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2024-05-08
卷期号:19 (5): e0302100-e0302100
标识
DOI:10.1371/journal.pone.0302100
摘要
M-type phospholipase A2 receptor (PLA2R) is a major auto-antigen of primary membranous nephropathy(PMN). Anti-PLA2R antibody levels are closely associated with disease severity and therapeutic effectiveness. Analysis of PLA2R antigen epitope reactivity may have a greater predictive value for remission compared with total PLA2R-antibody level. This study aims to elucidate the relationship between domain-specific antibody levels and clinical outcomes of PMN.
科研通智能强力驱动
Strongly Powered by AbleSci AI