Research Advance on Enantioselective Transition Metal-Catalyzed Hydroacylation Reactions

Transition metal-catalyzed hydroacylation reaction of aldehydes with π-unsaturated compounds provides an economical and efficient method for the construction of C-C bonds, not only allowing readily available starting materials to be used as substrates, but also featuring high atom and step economy.Therefore, the reaction has received continuous and extensive attention during the past several decades.The advances on enantioselective transition metal-catalyzed hydroacylation reactions are summarized, focusing on reaction types, asymmetric strategies and reaction mechanisms.