电解
电化学
化学
组合化学
酒精氧化
氧化还原
电合成
还原(数学)
无机化学
催化作用
有机化学
酒
电极
电解质
物理化学
作者
Sheng Zhang,Lijun Li,Jingjing Li,Jianxue Shi,Kun Xu,Wenchao Gao,Luyi Zong,Guigen Li,Michael Findlater
标识
DOI:10.1002/ange.202015230
摘要
Arylation of carbonyls, one of the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochemical arylation can fill the gap. By taking advantage of synthetic electrochemistry, commercially available aldehydes (ketones) and benzylic alcohols can be readily arylated to provide a general and scalable access to structurally diverse alcohols (97 examples, >10 gram-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochemical technology, was employed to transform low-value alcohols into more useful alcohols. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral α-arylation of benzylic alcohols.
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