CCR1
伪足
癌症研究
肿瘤微环境
趋化因子
生物
细胞生物学
趋化因子受体
胶质瘤
免疫学
免疫系统
肿瘤细胞
肌动蛋白
作者
Xiang Zhang,Lu Chen,Weiqi Dang,Mianfu Cao,Jin Xiao,Sheng‐Qing Lv,Wenjie Jiang,Xiaohong Yao,Huimin Lu,Jingya Miao,Yan Wang,Shanshan Yu,Yi‐Fang Ping,Xindong Liu,You‐Hong Cui,Xia Zhang,Xiu‐Wu Bian
标识
DOI:10.1038/s41374-019-0345-3
摘要
Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains undefined. In this study, we demonstrate that chemokine (C-C motif) ligand 8 (CCL8) is highly expressed by TAMs and contributes to pseudopodia formation by GBM cells. The presence of CCL8 in the glioma microenvironment promotes progression of tumor cells. Moreover, CCL8 induces invasion and stem-like traits of GBM cells, and CCR1 and CCR5 are the main receptors that mediate CCL8-induced biological behavior. Finally, CCL8 dramatically activates ERK1/2 phosphorylation in GBM cells, and blocking TAM-secreted CCL8 by neutralized antibody significantly decreases invasion of glioma cells. Taken together, our data reveal that CCL8 is a TAM-associated factor to mediate invasion and stemness of GBM, and targeting CCL8 may provide an insight strategy for GBM treatment.
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