摘要
HomeCirculationVol. 38, No. 1s5Aortic Stenosis Free AccessResearch ArticleAboutSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticleAortic Stenosis JOHN ROSSJR. and EUGENE BRAUNWALD JOHN ROSSJR.JOHN ROSSJR. From the Cardiology Branch, National Heart Institute, Bethesda, Maryland. and EUGENE BRAUNWALDEUGENE BRAUNWALD From the Cardiology Branch, National Heart Institute, Bethesda, Maryland. Originally published1 Jul 1968https://doi.org/10.1161/01.CIR.38.1S5.V-61Circulation. 1968;38:V-61–V-67"Aortic Stenosis." Circulation, 38(1s5), pp. V-61–V-67 Previous Back to top Next FiguresReferencesRelatedDetailsCited ByCrousillat D, Amponsah D, Camacho A, Kandanelly R, Bapat D, Chen C, Selberg A, Shaqdan A, Tanguturi V, Picard M, Hung J and Elmariah S (2022) Racial and Ethnic Differences in the Clinical Diagnosis of Aortic Stenosis, Journal of the American Heart Association, 11:24, Online publication date: 20-Dec-2022.O’Brien K (2022) Lipoproteins and Calcific Aortic Valve Disease: Hardening Evidence?, Arteriosclerosis, Thrombosis, and Vascular Biology, 42:11, (1321-1323), Online publication date: 1-Nov-2022.Strom J, Xu J, Sun T, Song Y, Sevilla-Cazes J, Almarzooq Z, Markson L, Wadhera R and Yeh R (2022) Characterizing the Accuracy of International Classification of Diseases, Tenth Revision Administrative Claims for Aortic Valve Disease, Circulation: Cardiovascular Quality and Outcomes, 15:10, (e009162), Online publication date: 1-Oct-2022.Bortnick A, Buzkova P, Otvos J, Jensen M, Tsai M, Budoff M, Mackey R, El Khoudary S, Favari E, Kim R, Rodriguez C, Thanassoulis G and Kizer J (2022) High-Density Lipoprotein and Long-Term Incidence and Progression of Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, 42:10, (1272-1282), Online publication date: 1-Oct-2022.Jurgens C, Lee C, Aycock D, Masterson Creber R, Denfeld Q, DeVon H, Evers L, Jung M, Pucciarelli G, Streur M and Konstam M (2022) State of the Science: The Relevance of Symptoms in Cardiovascular Disease and Research: A Scientific Statement From the American Heart Association, Circulation, 146:12, (e173-e184), Online publication date: 20-Sep-2022. Stassen J, Ewe S, Butcher S, Amanullah M, Mertens B, Hirasawa K, Singh G, Sin K, Ding Z, Pio S, Sia C, Chew N, Kong W, Poh K, Cohen D, Généreux P, Leon M, Ajmone Marsan N, Delgado V and Bax J (2022) Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis, Heart, 10.1136/heartjnl-2022-320886, (heartjnl-2022-320886) Flannery L, Etiwy M, Camacho A, Liu R, Patel N, Tavil‐Shatelyan A, Tanguturi V, Dal‐Bianco J, Yucel E, Sakhuja R, Jassar A, Langer N, Inglessis I, Passeri J, Hung J and Elmariah S (2022) Patient‐ and Process‐Related Contributors to the Underuse of Aortic Valve Replacement and Subsequent Mortality in Ambulatory Patients With Severe Aortic Stenosis, Journal of the American Heart Association, 11:11, Online publication date: 7-Jun-2022. Tomey M, Camaj A, Kini A and Sharma S (2022) Aortic Valvuloplasty and Large‐Bore Percutaneous Arterial Access Interventional Cardiology, 10.1002/9781119697367.ch55, (573-583), Online publication date: 3-Jun-2022. Yokoyama Y, Takagi H and Kuno T (2022) Early surgery versus conservative management of asymptomatic severe aortic stenosis: A meta-analysis, The Journal of Thoracic and Cardiovascular Surgery, 10.1016/j.jtcvs.2020.06.078, 163:5, (1778-1785.e5), Online publication date: 1-May-2022. Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A and Leon M (2022) Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials, Journal of the Society for Cardiovascular Angiography & Interventions, 10.1016/j.jscai.2022.100383, (100383), Online publication date: 1-May-2022. Ali A, Mather J, McMahon S, Curtis L, Hoover N, Ayer C, Amer M, Dibble T, Roper L, Orlando R and McKay R (2022) Racial and Ethnic Disparities in the Use of Transcatheter Aortic Valve Replacement in the State of Connecticut, Cardiovascular Revascularization Medicine, 10.1016/j.carrev.2021.06.120, 37, (7-12), Online publication date: 1-Apr-2022. Gaede L, Blumenstein J, Eckel C, Grothusen C, Tiyerili V, Sötemann D, Nef H, Elsässer A, Achenbach S and Möllmann H (2022) Transcatheter-based aortic valve replacement vs. isolated surgical aortic valve replacement in 2020, Clinical Research in Cardiology, 10.1007/s00392-022-02006-1 Ueda D, Yamamoto A, Ehara S, Iwata S, Abo K, Walston S, Matsumoto T, Shimazaki A, Yoshiyama M and Miki Y (2021) Artificial intelligence-based detection of aortic stenosis from chest radiographs, European Heart Journal - Digital Health, 10.1093/ehjdh/ztab102, 3:1, (20-28), Online publication date: 24-Mar-2022. Dayawansa N, Baratchi S and Peter K (2022) Uncoupling the Vicious Cycle of Mechanical Stress and Inflammation in Calcific Aortic Valve Disease, Frontiers in Cardiovascular Medicine, 10.3389/fcvm.2022.783543, 9 Li S, Patel N, Flannery L, Selberg A, Kandanelly R, Morrison F, Kim J, Tanguturi V, Crousillat D, Shaqdan A, Inglessis I, Shah P, Passeri J, Kaneko T, Jassar A, Langer N, Turchin A and Elmariah S (2022) Trends in Utilization of Aortic Valve Replacement for Severe Aortic Stenosis, Journal of the American College of Cardiology, 10.1016/j.jacc.2021.11.060, 79:9, (864-877), Online publication date: 1-Mar-2022. Bohbot Y (2022) Le rétrécissement aortique serré asymptomatique : quel suivi, quelle prise en charge au regard des recommandations récentes ?, Archives des Maladies du Coeur et des Vaisseaux - Pratique, 10.1016/j.amcp.2021.12.004, 2022:306, (3-8), Online publication date: 1-Mar-2022. Kvaslerud A, Gude E, Eriksen G, Andreassen A, Gullestad L and Broch K (2022) Diastolic Dysfunction Is Unmasked on Exercise in Patients With Asymptomatic, Severe Aortic Stenosis: An Invasive Hemodynamic Study, Circulation: Heart Failure, 15:2, Online publication date: 1-Feb-2022. Bowers M, Ganot G, Malito L, Kondori B, Ezechukwu A, Svedlund F and James B (2022) Failure Analysis of Medical Devices, Journal of Failure Analysis and Prevention, 10.1007/s11668-021-01332-2, 22:1, (154-180), Online publication date: 1-Feb-2022. Chai J, Mohiaddin H, Mandal A, Gan J, Hirani T, Sholapurkar R and Missouris C (2022) Role of open access echocardiography in detection of cardiac structural and functional abnormalities, Postgraduate Medical Journal, 10.1136/postgradmedj-2021-141195, (postgradmedj-2021-141195) Pankayatselvan V, Raber I, Playford D, Stewart S, Strange G and Strom J (2022) Moderate aortic stenosis: culprit or bystander?, Open Heart, 10.1136/openhrt-2021-001743, 9:1, (e001743), Online publication date: 1-Jan-2022. Luciani M, Ruschitzka F and Camici G (2022) Cardiovascular Ageing Senior Trauma Patients, 10.1007/978-3-030-91483-7_2, (13-21), . Perpetua E and Levin D (2022) Anatomy and Pathophysiology of Valvular Heart Disease Valvular Heart Disease, 10.1007/978-3-030-86233-6_2, (15-56), . Park K, Park T, Jo Y, Cho Y, Park J, Kim M and Kim Y (2021) Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis, Cardiovascular Ultrasound, 10.1186/s12947-020-00234-x, 19:1, Online publication date: 1-Dec-2021. Kim H, Kang D, Park H, Ahn J, Kim J, Kim S, Ok Y, Lee S, Pyo W, Ko E, Lee S, Kim D, Park S, Park D and Choo S (2021) Comparison of Sutureless Bioprosthetic Valve With Surgical or TAVR for Severe Aortic Stenosis, JACC: Asia, 10.1016/j.jacasi.2021.08.007, 1:3, (317-329), Online publication date: 1-Dec-2021. Raghav V, Midha P, Sharma R, Babaliaros V and Yoganathan A (2021) Transcatheter aortic valve thrombosis: a review of potential mechanisms, Journal of The Royal Society Interface, 10.1098/rsif.2021.0599, 18:184, Online publication date: 1-Nov-2021. Oancea A, Furnică C, Chistol R, Mitu F, Leon-Constantin M and Tinică G (2021) Surgical versus Transvalvular Aortic Valve Replacement in Elderly Patients—The Impact of Frailty, Diagnostics, 10.3390/diagnostics11101861, 11:10, (1861) Sevilla T, Revilla-Orodea A and San Román J (2021) Timing of Intervention in Asymptomatic Patients with Aortic Stenosis, European Cardiology Review, 10.15420/ecr.2021.11, 16 Maffeis C, Benfari G, Nistri S, Ribichini F and Rossi A (2021) Clinical impact of mitral regurgitation in aortic valve stenosis: Insight from effective regurgitant orifice area, Echocardiography, 10.1111/echo.15184, 38:9, (1604-1611), Online publication date: 1-Sep-2021. Maeda M, Omori T, Kagawa S, Uno G, Rader F, Siegel R and Shiota T (2021) Impact of Systolic Blood Pressure on Heart Failure Symptoms With Moderate Aortic Stenosis, The American Journal of Cardiology, 10.1016/j.amjcard.2021.06.018, 155, (96-102), Online publication date: 1-Sep-2021. Bowers M, Ganot G, Malito L, Kondori B, Ezechukwu A, Svedlund F and James B (2021) Failure Analysis of Medical Devices Analysis and Prevention of Component and Equipment Failures, 10.31399/asm.hb.v11A.a0006811, (736-753) Gillam L and Mediratta A (2021) Myocardial Contraction Fraction in Low-Gradient Aortic Stenosis: Updating an Old Tool for a New Application, Circulation: Cardiovascular Imaging, 14:8, Online publication date: 1-Aug-2021. Koutsoukis A, Nahory L, Deguillard C, Juguet W, Nguyen A, Fard D, Folliguet T, Fiore A, Bergoend E, Gallet R, Mouillet G, Derumeaux G, Vincent F, Teiger E, Lim P and Ternacle J (2020) Timing of aortic valve replacement in high-gradient severe aortic stenosis: impact of left ventricular ejection fraction, Acta Cardiologica, 10.1080/00015385.2020.1851495, 76:5, (517-524), Online publication date: 16-Jul-2021. Petersen J, Kloth B, Iqbal S, Reichenspurner H, Geelhoed B, Schnabel R, Eschenhagen T, Christ T and Girdauskas E (2021) Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease, European Journal of Cardio-Thoracic Surgery, 10.1093/ejcts/ezab004, 60:1, (56-63), Online publication date: 14-Jul-2021. Kawada Y, Kitada S, Hachiya K, Kato M, Nakasuka K, Kikuchi S, Seo Y and Ohte N (2021) Left Ventricular Hypertrophic Change Indicating Poor Prognosis in Patients With Normal-Flow, Low-Gradient Severe Aortic Stenosis With Preserved Left Ventricular Ejection Fraction, Circulation Reports, 10.1253/circrep.CR-21-0011, 3:6, (345-353), Online publication date: 10-Jun-2021. Ferrara J, Deharo P, Resseguier N, Porto A, Jaussaud N, Morera P, Amanatiou C, Gariboldi V, Collart F, Cuisset T and Theron A (2021) Rapid deployment versus trans‐catheter aortic valve replacement in intermediate‐risk patients: A propensity score analysis, Journal of Cardiac Surgery, 10.1111/jocs.15483, 36:6, (2004-2012), Online publication date: 1-Jun-2021. Feldman D, Romashko M, Koethe B, Patel S, Rastegar H, Zhan Y, Resor C, Connors A, Kimmelstiel C, Allen D, Weintraub A and Wessler B (2021) Comorbidity Burden and Adverse Outcomes After Transcatheter Aortic Valve Replacement, Journal of the American Heart Association, 10:10, Online publication date: 18-May-2021. KÜCKEN T, EDLINGER C, OKAMOTO M, BANNEHR M, JIRAK P, LICHTENAUER M, HAASE-FIELITZ A, KRIZANIC F and BUTTER C How low is "low-flow" in aortic stenosis? A retrospective analysis of patients with true low-flow/low-gradient aortic stenosis undergoing TAVI, Minerva Medica, 10.23736/S0026-4806.20.06817-2, 112:3 EDLINGER C, KRIZANIC F, BUTTER C, BANNEHR M, NEUSS M, FEJZIC D, HOPPE U and LICHTENAUER M Economic assessment of traditional surgical valve replacement versus use of transfemoral intervention in degenerative aortic stenosis, Minerva Medica, 10.23736/S0026-4806.20.06640-9, 112:3 Bing R and Dweck M (2020) Management of asymptomatic severe aortic stenosis: check or all in?, Heart, 10.1136/heartjnl-2020-317160, 107:10, (842-850), Online publication date: 1-May-2021. Boskovski M and Gleason T (2021) Current Therapeutic Options in Aortic Stenosis, Circulation Research, 128:9, (1398-1417), Online publication date: 30-Apr-2021.Driscoll K, Cruz A and Butcher J (2021) Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease, Circulation Research, 128:9, (1344-1370), Online publication date: 30-Apr-2021.Perry A and Li S (2021) Optimal Threshold of Left Ventricular Ejection Fraction for Aortic Valve Replacement in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta‐Analysis, Journal of the American Heart Association, 10:7, Online publication date: 6-Apr-2021. Singh K, Win K, Camuglia A and Provenzano S (2021) Emergency treatment of acute decompensated critical aortic stenosis with transcatheter aortic valve implantation, Future Cardiology, 10.2217/fca-2020-0092, 17:2, (315-320), Online publication date: 1-Mar-2021. Ring L, Shah B, Bhattacharyya S, Harkness A, Belham M, Oxborough D, Pearce K, Rana B, Augustine D, Robinson S and Tribouilloy C (2021) Echocardiographic assessment of aortic stenosis: a practical guideline from the British Society of Echocardiography, Echo Research & Practice, 10.1530/ERP-20-0035, 8:1, (G19-G59), Online publication date: 1-Mar-2021. Whitener S, Francis L, McMurray J and Whitener G (2020) Asymptomatic Severe Aortic Stenosis and Noncardiac Surgery, Seminars in Cardiothoracic and Vascular Anesthesia, 10.1177/1089253220969576, 25:1, (19-28), Online publication date: 1-Mar-2021. Starnes V, Elsayed R, Cohen R, Olds A, Bojko M, Mack W, Cutri R, Baertsch H, Baker C, Kumar S and Bowdish M (2021) Long-term outcomes with the pulmonary autograft inclusion technique in adults with bicuspid aortic valves undergoing the Ross procedure, The Journal of Thoracic and Cardiovascular Surgery, 10.1016/j.jtcvs.2021.01.101, Online publication date: 1-Feb-2021. Fletcher A, Singh T, Syed M and Dweck M (2021) Imaging aortic valve calcification: significance, approach and implications, Clinical Radiology, 10.1016/j.crad.2020.04.007, 76:1, (15-26), Online publication date: 1-Jan-2021. Miller R, Marlevi D, Zhang W, Hirschvogel M, Hadjicharalambous M, Capilnasiu A, Balmus M, Hager S, Jilberto J, Bonini M, Wittgenstein A, Ahmed Y and Nordsletten D (2021) Modeling Biomechanics in the Healthy and Diseased Heart Modeling Biomaterials, 10.1007/978-3-030-88084-2_5, (141-239), . Rihal C, Simard T and Holmes D (2021) 2000s: Structural Heart Disease The Mayo Clinic Cardiac Catheterization Laboratory, 10.1007/978-3-030-79329-6_7, (155-185), . Machida A, Funaki T, Nishida K, Imai R, Nakaoka Y, Seki S, Baba Y, Kubo T, Yamasaki N, Kitaoka H, Kubokawa S, Sakaeda H, Kawai K, Hamashige N and Doi Y (2020) Premature Onset Aortic Stenosis in Systemic Sclerosis: A Report of a Series of Cases, Internal Medicine, 10.2169/internalmedicine.5226-20, 59:24, (3177-3181), Online publication date: 15-Dec-2020. Chien S, Clark C, Maheshwari S, Koutsogiannidis C, Zamvar V, Giordano V, Lim K and Pessotto R (2020) Benefits of rapid deployment aortic valve replacement with a mini upper sternotomy, Journal of Cardiothoracic Surgery, 10.1186/s13019-020-01268-y, 15:1, Online publication date: 1-Dec-2020. San Román J, Vilacosta I, Antunes M, Iung B, Lopez J and Schäfers H (2020) The ‘wait for symptoms’ strategy in asymptomatic severe aortic stenosis, Heart, 10.1136/heartjnl-2020-317323, 106:23, (1792-1797), Online publication date: 1-Dec-2020. Yong G, Walton T, Ng M, Gurvitch R, Worthley S, Whitbourn R, Jepson N, Bhindi R, Shang K and Sinhal A (2020) Performance and Safety of Transfemoral TAVI With SAPIEN XT in Australian Patients With Severe Aortic Stenosis at Intermediate Surgical Risk: SOLACE–AU Trial, Heart, Lung and Circulation, 10.1016/j.hlc.2020.04.010, 29:12, (1839-1846), Online publication date: 1-Dec-2020. Ducharme-Smith A, Chahal C, Sawatari H, Podboy A, Sherif A, Scott C, Brady P, Gersh B, Somers V, Nkomo V and Pellikka P (2020) Relationship Between Anemia and Sudden Cardiac Death in Patients With Severe Aortic Stenosis, The American Journal of Cardiology, 10.1016/j.amjcard.2020.09.007, 136, (107-114), Online publication date: 1-Dec-2020. Gaede L, Sitges M, Neil J, Selvi E, Woan W, Derks R and Möllmann H (2020) European heart health survey 2019, Clinical Cardiology, 10.1002/clc.23478, 43:12, (1539-1546), Online publication date: 1-Dec-2020. Crousillat D, Namasivayam M and Passeri J (2020) Severe, Symptomatic Aortic Stenosis: an Update on the Diagnostic and Treatment Tools in Our Arsenal, Current Treatment Options in Cardiovascular Medicine, 10.1007/s11936-020-00847-5, 22:11, Online publication date: 1-Nov-2020. Popovic B, Molho A, Varlot J, Fay R, Metzdorf P, Elfarra M, Maureira P, Juillière Y, Huttin O and Camenzind E (2020) Prognostic influence of acute decompensated heart failure in patients planned for transcatheter aortic valve implantation, Catheterization and Cardiovascular Interventions, 10.1002/ccd.28813, 96:5, Online publication date: 1-Nov-2020. Bartoli-Leonard F and Aikawa E (2020) Heart Valve Disease: Challenges and New Opportunities, Frontiers in Cardiovascular Medicine, 10.3389/fcvm.2020.602271, 7 Anand V, Adigun R, Thaden J, Pislaru S, Pellikka P, Nkomo V, Greason K and Pislaru C (2019) Predictive value of left ventricular diastolic chamber stiffness in patients with severe aortic stenosis undergoing aortic valve replacement, European Heart Journal - Cardiovascular Imaging, 10.1093/ehjci/jez292, 21:10, (1160-1168), Online publication date: 1-Oct-2020. Matthew Brennan J, Leon M, Sheridan P, Boero I, Chen Q, Lowenstern A, Thourani V, Vemulapalli S, Thomas K, Wang T and Peterson E (2020) Racial Differences in the Use of Aortic Valve Replacement for Treatment of Symptomatic Severe Aortic Valve Stenosis in the Transcatheter Aortic Valve Replacement Era, Journal of the American Heart Association, 9:16, Online publication date: 18-Aug-2020. Scully P, Patel K, Treibel T, Thornton G, Hughes R, Chadalavada S, Katsoulis M, Hartman N, Fontana M, Pugliese F, Sabharwal N, Newton J, Kelion A, Ozkor M, Kennon S, Mullen M, Lloyd G, Menezes L, Hawkins P and Moon J (2020) Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation, European Heart Journal, 10.1093/eurheartj/ehaa170, 41:29, (2759-2767), Online publication date: 1-Aug-2020. Silva K and Emter C (2020) Large Animal Models of Heart Failure, JACC: Basic to Translational Science, 10.1016/j.jacbts.2020.04.011, 5:8, (840-856), Online publication date: 1-Aug-2020. Khan J, Khalid N, Shlofmitz E, Forrestal B, Yerasi C, Case B, Chezar-Azerrad C, Musallam A, Rogers T and Waksman R (2020) Guidelines for Balancing Priorities in Structural Heart Disease During the COVID-19 Pandemic, Cardiovascular Revascularization Medicine, 10.1016/j.carrev.2020.05.040, 21:8, (1030-1033), Online publication date: 1-Aug-2020. Mourino-Alvarez L, Martin-Rojas T, Corros-Vicente C, Corbacho-Alonso N, Padial L, Solis J and Barderas M (2020) Patient Management in Aortic Stenosis: Towards Precision Medicine through Protein Analysis, Imaging and Diagnostic Tests, Journal of Clinical Medicine, 10.3390/jcm9082421, 9:8, (2421) Greene C, Jaatinen K, Wang H, Koyano T, Bilbao M and Woo Y (2020) Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves, Genes, 10.3390/genes11070789, 11:7, (789) Taniguchi T, Morimoto T, Takeji Y, Kato T and Kimura T (2020) Contemporary issues in severe aortic stenosis: review of current and future strategies from the Contemporary Outcomes after Surgery and Medical Treatment in Patients with Severe Aortic Stenosis registry, Heart, 10.1136/heartjnl-2019-315672, 106:11, (802-809), Online publication date: 1-Jun-2020. Rajamannan N, Moura L and Best P (2020) Bench to bedside defining calcific aortic valve disease: osteocardiology, Expert Review of Cardiovascular Therapy, 10.1080/14779072.2020.1757431, 18:5, (239-247), Online publication date: 3-May-2020. Spaccarotella C, Mongiardo A, Curcio A, De Rosa S and Indolfi C (2020) Will transcatheter aortic valve implantation represent the choice treatment for all patients who need a biological valve?, Journal of Cardiovascular Medicine, 10.2459/JCM.0000000000000944, 21:5, (345-348), Online publication date: 1-May-2020. Bohbot Y, Renard C, Manrique A, Levy F, Maréchaux S, Gerber B and Tribouilloy C (2020) Usefulness of Cardiac Magnetic Resonance Imaging in Aortic Stenosis, Circulation: Cardiovascular Imaging, 13:5, Online publication date: 1-May-2020. Andrew J, DivyaVarshini M, Barjo P and Tigga I (2020) Spine Magnetic Resonance Image Segmentation Using Deep Learning Techniques 2020 6th International Conference on Advanced Computing and Communication Systems (ICACCS), 10.1109/ICACCS48705.2020.9074218, 978-1-7281-5196-0, (945-950) Barnhart G, Martin R, Thomas J and McCarthy P (2020) The Need for Echocardiography Alerts for Aortic Stenosis: The Time Has Come, Journal of the American Society of Echocardiography, 10.1016/j.echo.2019.11.005, 33:3, (355-357), Online publication date: 1-Mar-2020. Nuis R, Goudzwaard J, de Ronde-Tillmans M, Kroon H, Ooms J, van Wiechen M, Geleijnse M, Zijlstra F, Daemen J, Van Mieghem N, Mattace-Raso F, Lenzen M and de Jaegere P (2020) Impact of Valvulo-Arterial Impedance on Long-Term Quality of Life and Exercise Performance After Transcatheter Aortic Valve Replacement, Circulation: Cardiovascular Interventions, 13:1, Online publication date: 1-Jan-2020. Barker C and Reardon M (2020) Transcatheter aortic valve replacement Emerging Technologies for Heart Diseases, 10.1016/B978-0-12-813706-2.00020-8, (399-415), . Carabello B, Alwair H and Nekkanti R (2020) Comprehensive Approach to Aortic Valve Disease Valvular Heart Disease, 10.1007/978-1-4471-2840-3_5, (71-101), . Guedeney P, Huchet F, Manigold T, Rouanet S, Balagny P, Leprince P, Lebreton G, Letocart V, Barthelemy O, Vicaut E, Montalescot G, Guerin P and Collet J (2019) Incidence of, risk factors for and impact of readmission for heart failure after successful transcatheter aortic valve implantation, Archives of Cardiovascular Diseases, 10.1016/j.acvd.2019.09.008, 112:12, (765-772), Online publication date: 1-Dec-2019. Brandenburg V, Schuh A and Kramann R (2019) Valvular Calcification in Chronic Kidney Disease, Advances in Chronic Kidney Disease, 10.1053/j.ackd.2019.10.004, 26:6, (464-471), Online publication date: 1-Nov-2019. Batchelor W, Anwaruddin S, Ross L, Alli O, Young M, Horne A, Cestoni A, Welt F and Mehran R (2019) Aortic Valve Stenosis Treatment Disparities in the Underserved, Journal of the American College of Cardiology, 10.1016/j.jacc.2019.08.1035, 74:18, (2313-2321), Online publication date: 1-Nov-2019. Cacciapuoti F (2019) Homocysteine can induce calcific aorta valve stenosis with or without coronary artery disease in the elderly surgical and medical measures, Journal of Cardiology & Current Research, 10.15406/jccr.2019.12.00453, 12:5, (121-125) Kwon S and Gopal A (2019) Hemodynamic Classifications of Aortic Stenosis and Relevance to Prognosis Aortic Stenosis - Current Perspectives, 10.5772/intechopen.86707 Kumar Monigari N and Agarwal A (2019) Transcatheter Aortic Valve Replacement: Clinical Indications and Outcomes Aortic Stenosis - Current Perspectives, 10.5772/intechopen.84909 Mohamad Ali F, Wilson V and Nair R (2019) Low Flow Low Gradient Severe Aortic Stenosis: Diagnosis and Treatment Aortic Stenosis - Current Perspectives, 10.5772/intechopen.84435 Leal O, Sanchez-Valenzuela D and Bustamante-Munguira J (2019) Current Management of Severe Aortic Stenosis in Intermediate Risk Patients Aortic Stenosis - Current Perspectives, 10.5772/intechopen.83422 Ben-Assa E, Brown J, Keshavarz-Motamed Z, de la Torre Hernandez J, Leiden B, Olender M, Kallel F, Palacios I, Inglessis I, Passeri J, Shah P, Elmariah S, Leon M and Edelman E (2019) Ventricular stroke work and vascular impedance refine the characterization of patients with aortic stenosis, Science Translational Medicine, 10.1126/scitranslmed.aaw0181, 11:509, Online publication date: 11-Sep-2019. Piñón M, Paredes E, Acuña B, Raposeiras S, Casquero E, Ferrero A, Torres I, Legarra J, Pradas G, Barreiro-Morandeira F and Rodriguez-Pascual C (2019) Frailty, disability and comorbidity: different domains lead to different effects after surgical aortic valve replacement in elderly patients, Interactive CardioVascular and Thoracic Surgery, 10.1093/icvts/ivz093, 29:3, (371-377), Online publication date: 1-Sep-2019. Raju S, Eisenberg N, Montbriand J, Cusimano R, Feindel C, Ouzounian M, Horlick E, Osten M, Tsang W and Roche-Nagle G (2019) Vascular Complications and Procedures Following Transcatheter Aortic Valve Implantation, European Journal of Vascular and Endovascular Surgery, 10.1016/j.ejvs.2019.03.014, 58:3, (437-444), Online publication date: 1-Sep-2019. Avula S, Mungee S and Barzallo M (2019) Successful minimal approach transcatheter aortic valve replacement in an allograft heart recipient 19 years post transplantation for severe aortic stenosis: A case report, World Journal of Cardiology, 10.4330/wjc.v11.i8.209, 11:8, (209-212), Online publication date: 26-Aug-2019. McConkey H, Marber M, Chiribiri A, Pibarot P, Redwood S and Prendergast B (2019) Coronary Microcirculation in Aortic Stenosis, Circulation: Cardiovascular Interventions, 12:8, Online publication date: 1-Aug-2019. Al-Shaibi K, Ahmed W, Abukhudair W, Nosir Y, Al-Shaibi A, Kateb R and Alasnag M (2019) TAVR in Patients with a Low STS Score: A Cohort Study with a Mean Follow Up of 2 Years, Cardiovascular Revascularization Medicine, 10.1016/j.carrev.2018.10.002, 20:8, (695-699), Online publication date: 1-Aug-2019. Ito S, Miranda W and Oh J (2019) Assessment of Aortic Stenosis Beyond the Aortic Valve Area, Structural Heart, 10.1080/24748706.2019.1627445, 3:4, (268-279), Online publication date: 1-Jul-2019. Goliasch G and Mascherbauer J (2019) The Authors Reply, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2019.03.023, 12:6, (1114), Online publication date: 1-Jun-2019. Ben-Shoshan J, Zahler D, Banai S and Finkelstein A (2019) The Eye of the Beholder, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2019.02.030, 12:6, (1113-1114), Online publication date: 1-Jun-2019. Raghav V, Clifford C, Midha P, Okafor I, Thurow B and Yoganathan A (2019) Three-dimensional extent of flow stagnation in transcatheter heart valves, Journal of The Royal Society Interface, 10.1098/rsif.2019.0063, 16:154, (20190063), Online publication date: 1-May-2019. Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S, Nagata Y, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S, Levine R and Otsuji Y (2019) Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis: association with reduced O 2 consumption by the whole body , American Journal of Physiology-Heart and Circulatory Physiology, 10.1152/ajpheart.00715.2018, 316:4, (H840-H848), Online publication date: 1-Apr-2019. Kim H, Kim J, Kim H, Ju M, Kang D, Lee S, Lee S, Ahn J, Kim D, Jung S, Park D, Song J, Choo S, Chung C, Song J, Lee J and Park S (2019) Impact of Valve Replacement on Long-Term Survival in Asymptomatic Patients With Severe Aortic Stenosis, The American Journal of Cardiology, 10.1016/j.amjcard.2019.01.035, 123:8, (1321-1328), Online publication date: 1-Apr-2019. Gaede L, Blumenstein J, Liebetrau C, Dörr O, Kim W, Hamm C, Elsässer A, Nef H and Möllmann H (2017) HerzklappenerkrankungenHeart valve disesases, Herz, 10.1007/s00059-017-4632-8, 44:2, (161-169), Online publication date: 1-Apr-2019. Delesalle G, Bohbot Y, Rusinaru D, Delpierre Q, Maréchaux S and Tribouilloy C (2019) Characteristics and Prognosis of Patients With Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction, Journal of the American Heart Association, 8:6, Online publication date: 19-Mar-2019. Ben-Shoshan J, Zahler D, Margolis G, Arbel Y, Konigstein M, Chorin E, Steinvil A, Keren G, Banai S and Finkelstein A (2019) Relation of Clinical Presentation of Aortic Stenosis and Survival Following Transcatheter Aortic Valve Implantation, The American Journal of Cardiology, 10.1016/j.amjcard.2018.12.009, 123:6, (961-966), Online publication date: 1-Mar-2019. Bing R, Cavalcante J, Everett R, Clavel M, Newby D and Dweck M (2019) Imaging and Impact of Myocardial Fibrosis in Aortic Stenosis, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2018.11.026, 12:2, (283-296), Online publication date: 1-Feb-2019. Carabello B (2019) Syncope in Aortic Stenosis, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2018.10.011, 12:2, (233-235), Online publication date: 1-Feb-2019. Goliasch G, Kammerlander A, Nitsche C, Dona C, Schachner L, Öztürk B, Binder C, Duca F, Aschauer S, Laufer G, Hengstenberg C, Bonderman D and Mascherbauer J (2019) Syncope, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2018.09.020, 12:2, (225-232), Online publication date: 1-Feb-2019. Mateescu A, Călin A, Beladan C, Roşca M, Enache R, Băicuş C, Botezatu S, Ginghină C and Popescu B (2019) Left Atrial Dysfunction as an Independent Correlate of Heart Failure Symptoms in Patients With Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction, Journal of the American Society of Echocardiography, 10.1016/j.echo.2018.11.007, 32:2, (257-266), Online publication date: 1-Feb-2019. Ahmad S, Tirilomis P, Pabel S, Dybkova N, Hartmann N, Molina C, Tirilomis T, Kutschka I, Frey N, Maier L, Hasenfuss G, Streckfuss-Bömeke K and Sossalla S (2018) The functional consequences of sodium channel Na V 1.8 in human left ventricular hypertrophy , ESC Heart Failure, 10.1002/ehf2.12378, 6:1, (154-163), Online publication date: 1-Feb-2019. Marsh K, Hawken N, Brookes E, Kuehn C and Liden B (2021) Patient-centered benefit-risk analysis of transcatheter aortic valve replacement,