Metabotropic Glutamate Receptor 5: A Potential Molecular Switch and Beyond

SEE CORRESPONDING ARTICLE ON PAGE 104 Metabotropic Glutamate Receptor 5 in Amygdala Target Neurons Regulates Susceptibility to Chronic Social StressBiological PsychiatryVol. 92Issue 2PreviewMetabotropic glutamate receptor 5 (mGluR5) has been implicated in stress-related psychiatric disorders, particularly major depressive disorder. Although growing evidence supports the proresilient role of mGluR5 in corticolimbic circuitry in the depressive-like behaviors following chronic stress exposure, the underlying neural mechanisms, including circuits and molecules, remain unknown. Full-Text PDF