免疫组织化学
医学
西妥昔单抗
表皮生长因子受体
结直肠癌
癌症研究
帕尼单抗
生长因子受体
肿瘤科
表皮生长因子
受体
癌症
人口
病理
内科学
环境卫生
作者
David C. Spaulding,Betsy O. Spaulding
标识
DOI:10.1053/sonc.2002.35647
摘要
The efficacies of targeted therapies for cancer treatment are dependent on the expression of the targeted molecule in the tumors of the treated patient population. Immunohistochemistry is an attractive assay format for determining protein expression in biopsies of solid tumors, and is widely used in pathology laboratories. An optimized immunohistochemistry assay for the epidermal growth factor receptor (EGFR) has been developed for the detection of EGFR in colorectal, head and neck, and other tumors that express EGFR, and the assay is being used in colorectal cancer trials of IMC-C225 to select patients for treatment. The specificity of the assay and the detection technology used will be described, along with other assay methodologies and applications for EGFR testing.
科研通智能强力驱动
Strongly Powered by AbleSci AI