亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Outcome of Cancer-Associated Venous Thromboembolism Is More Favorable among Patients with Hematologic Malignancies than in Those with Solid Tumors

医学 内科学 多发性骨髓瘤 肺栓塞 癌症 深静脉 血栓形成 置信区间 单变量分析 化疗 外科 静脉血栓形成 胃肠病学 多元分析
作者
Ramón Lecumberri,Pedro Ruiz-Artacho,Inna Tzoran,Benjamin Brenner,Dominique Farge-Bancel,Cihan Ay,Vladimir Rosa,Iria Francisco,Luis Hernández-Blasco,Javier Trujillo-Santos,Manuel Monreal
出处
期刊:Thrombosis and Haemostasis [Thieme Medical Publishers (Germany)]
卷期号:122 (09): 1594-1602 被引量:4
标识
DOI:10.1055/a-1777-4006
摘要

Abstract Background The natural history of patients with hematologic cancer and venous thromboembolism (VTE) has not been consistently evaluated. We aimed to compare the rates of symptomatic recurrent VTE, major bleeding, or death during anticoagulant therapy in patients with VTE associated with hematologic versus solid cancers. Methods Consecutive patients with active cancer recruited in RIETE were evaluated. Their baseline characteristics, treatments, and outcomes during the course of anticoagulation were compared. Univariate and multivariate competing-risk analyses were performed. Results As of December 2020, 16,694 patients with cancer and VTE were recruited. Of these, 1,062 (6.4%) had hematologic cancers. Hematologic patients were less likely to initially present with pulmonary embolism (46 vs. 55%) and more likely with upper extremity deep vein thrombosis (25 vs. 18%). They also were more likely to have severe thrombocytopenia at baseline (5.6 vs. 0.7%) or to receive chemotherapy (67 vs. 41%). During the course of anticoagulation (median, 150 vs. 127 days), 1,071 patients (6.4%) developed VTE recurrences, 806 (4.8%) suffered major bleeding, and 4,136 (24.8%) died. Patients with hematologic cancers had lower rates of recurrent VTE (rate ratio [RR]: 0.73; 95% confidence interval [CI]: 0.56–0.95), major bleeding (RR: 0.72; 95% CI: 0.53–0.98), or all-cause death (RR: 0.49; 95% CI: 0.41–0.57) than those with solid cancers. Patients with multiple myeloma showed the best outcomes. Conclusion Patients with hematologic cancers, particularly multiple myeloma, and VTE had better outcomes than those with solid cancers. These findings are relevant for the interpretation of previous clinical trials and the design of future studies.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
酸辣完成签到 ,获得积分10
22秒前
23秒前
英俊的铭应助Ninece采纳,获得10
52秒前
59秒前
Ninece发布了新的文献求助10
1分钟前
3211关注了科研通微信公众号
1分钟前
沙与沫完成签到 ,获得积分10
1分钟前
3211发布了新的文献求助10
1分钟前
1分钟前
发发发布了新的文献求助10
1分钟前
吃点水果保护局完成签到 ,获得积分10
1分钟前
烟花应助发发采纳,获得10
1分钟前
沉默的友安完成签到 ,获得积分10
2分钟前
斯文败类应助科研通管家采纳,获得10
2分钟前
852应助科研通管家采纳,获得10
4分钟前
4分钟前
Melody发布了新的文献求助10
4分钟前
852应助liudy采纳,获得10
4分钟前
5分钟前
liudy发布了新的文献求助10
5分钟前
大个应助Ninece采纳,获得10
5分钟前
5分钟前
Ninece发布了新的文献求助10
5分钟前
bkagyin应助滕焯采纳,获得10
5分钟前
5分钟前
滕焯发布了新的文献求助10
5分钟前
hahhhhhh2完成签到,获得积分10
6分钟前
SciGPT应助momo采纳,获得10
6分钟前
6分钟前
6分钟前
momo发布了新的文献求助10
6分钟前
搜集达人应助科研通管家采纳,获得10
6分钟前
岁末完成签到 ,获得积分10
6分钟前
6分钟前
wt发布了新的文献求助10
7分钟前
wt完成签到,获得积分10
7分钟前
cc完成签到,获得积分20
7分钟前
7分钟前
圆圆901234发布了新的文献求助10
7分钟前
无花果应助圆圆901234采纳,获得10
8分钟前
高分求助中
传播真理奋斗不息——中共中央编译局成立50周年纪念文集(1953—2003) 700
Technologies supporting mass customization of apparel: A pilot project 600
武汉作战 石川达三 500
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3811703
求助须知:如何正确求助?哪些是违规求助? 3355978
关于积分的说明 10378899
捐赠科研通 3072955
什么是DOI,文献DOI怎么找? 1687960
邀请新用户注册赠送积分活动 811831
科研通“疑难数据库(出版商)”最低求助积分说明 766877