生物
间充质干细胞
成牙本质细胞
牙髓(牙)
细胞生物学
转录组
神经嵴
电池类型
牙髓干细胞
间质细胞
门牙
细胞
病理
遗传学
基因表达
基因
医学
胚胎
癌症研究
生态学
作者
Dashzeveg Bayarsaihan,Badam Enkhmandakh,Anushree Vijaykumar,Paul Robson,Mina Mina
标识
DOI:10.1016/j.gep.2021.119228
摘要
The dental pulp is known to be highly heterogenous, comprising distinct cell types including mesenchymal stromal cells (MSCs), which represent neural-crest-derived cells with the ability to differentiate into multiple cell lineages. However, the cellular heterogeneity and the transcriptome signature of different cell clusters within the dental pulp remain to be established. To better understand discrete cell types, we applied a single-cell RNA sequencing strategy to establish the RNA expression profiles of individual dental pulp cells from 5- to 6-day-old mouse incisors. Our study revealed distinct subclasses of cells representing osteoblast, odontoblast, endothelial, pancreatic, neuronal, immune, pericyte and ameloblast lineages. Collectively, our research demonstrates the complexity and diversity of cell subclasses within the incisor dental pulp, thus providing a foundation for uncovering the molecular processes that govern cell fate decisions and lineage commitment in dental pulp-derived MSCs.
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