失调
免疫学
关节炎
免疫系统
肠道菌群
白细胞介素17
类风湿性关节炎
医学
炎症
反应性关节炎
生物
作者
Yuichi Maeda,Takashi Kurakawa,Eiji Umemoto,Daisuke Motooka,Yoshinaga Ito,Kazuyoshi Gotoh,Keiji Hirota,M. Matsushita,Yoki Furuta,Masashi Narazaki,Noriko Sakaguchi,Hisako Kayama,Shota Nakamura,Tetsuya Iida,Yukihiko Saeki,Atsushi Kumanogoh,Shimon Sakaguchi,Kiyoshi Takeda
摘要
We demonstrated that dysbiosis increases sensitivity to arthritis via activation of autoreactive T cells in the intestine. Autoreactive SKG mouse T cells are activated by dysbiotic microbiota in the intestine, causing joint inflammation. Dysbiosis is an environmental factor that triggers arthritis development in genetically susceptible mice.
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(2025-6-4)
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