Aim To explore hemogram charge during supplemeatary VP for postoperative chemotherapy with oral squamous cell carcinoma and the reason for charge.Methods Hemogram charges were reviewed in 81 cases of oral squamous cell carcinoma(2000~2005)with supplemenfary VP for postoperative chemotherapy.Results All of the patients'hemogram have changed.Change of WBC is the most significant(P0.05),and that of PLT ranks the second(P0.05)while that of RBC is not notable.But one week chemotherapy,Condition of hemogram restores as normal as pre-chemotherapy.Conclusion Patients' hemogram during supplementary VP for postoperative chemotherapy with oral squamous cell carcinoma may take temporary change and will restore to its normal evel after one week.