Relationship among angiography's blood flow (TIMI grade and TIM1 frame count) and intra-coronary Doppler flow velocity

Objective: To investigate the relationship among coronary angiography' s TIMI (thrombolysis in myocardial infarction) blood flow grade (TIMI - FG), TIMI frame count (TIMI - FC) and intra-coronary Doppler flow velocity (DFV). Methods: During 11 experimental animal model of mini-swine that accurately mimics human coronary stenosis by implantation of inflated balloon and 36 patients who underwent coronary arteriography, 17 patients with coronary heart disease after percutaneous transluminal coronary angioplasty (PTCA), the TIMI -FG and TIMI -Fc were observed and compared with intra-coronary Doppler flow velocity. Results: (1) In animal model, DFV and TIMI - FG decreased.TIMI -FC increased significantly (P0. 01 all) after balloon inflated; (2)After PTCA + stents ,DFV and TIMI -FG increased (P0. 05-0. 01), TIMI -FC decreased significantly (P0.05) in 25 lesion artery; (3) Angiography' s TIMI -FC negatively correlated with DFC in patients (r= - 0. 49--0. 58) and swine (r=-0. 41). The correlation rose (r=-0. 62--0. 66 in patients , r= - 0. 71 in swine) by compared change of TIMI - FGand TIMI-FC with change of DEV. Conclusion: TIMI-FC can be used for detection Doppler flow velocity especially for change of its.