RAC1
GTP酶
细胞生物学
Rac-GTP结合蛋白
造血
生物
鸟苷
祖细胞
干细胞
骨髓
信号转导
免疫学
生物化学
作者
Yi Gu,Marie–Dominique Filippi,José A. Cancelas,Jamie E. Siefring,Emily Williams,Aparna C. Jasti,Chad E. Harris,Andrew W. Lee,Rethinasamy Prabhakar,Simon J. Atkinson,David J. Kwiatkowski,David A. Williams
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2003-10-17
卷期号:302 (5644): 445-449
被引量:465
标识
DOI:10.1126/science.1088485
摘要
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1-/- but not Rac2-/- HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function.
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