Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA

Arginine metabolism stratifies MCs into pro-tumorigenic HAS and quiescent LAS subsets; ASL-high MCs constitute a metabolically wired, highly communicating population that fuels TNBC progression and furnishes an exploitable prognostic signature. OAT, a key HAS-associated gene, promotes breast cancer aggressiveness through proliferation, survival, and invasion.