Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: in silico , synthesis, and in vitro evaluation

Tetrahydrocarbazole-6-sulfonamides represent a versatile scaffold for selective inhibition of NOX2 and NOX4, with ASP5 and ASP20 identified as promising leads for targeting NOX-mediated oxidative stress in TBI.