Merkel cells release ATP in response to mechanical stimulation to mediate paracrine signalling

Human Merkel cells release ATP in response to mechanical stimulation, activating neighboring Merkel cells through purinergic receptors. This study reveals a previously unrecognized paracrine signaling mechanism within epidermal touch domes that may modulate tactile sensitivity. These findings provide new insight into non-neuronal sensory communication and potential roles in age-related or pathological sensory changes.