A Glutamine‐Metabolism‐Intervening Nanoplatform Activates Lipophagy to Potentiate Ferroptosis and Immune Activation in Breast Cancer

-MIL-101(Fe)), followed by surface coating for tumor-targeting. Experimental data reveal that Ce6-based photodynamic therapy synergizes with iron-mediated Fenton reaction, potently driving lipid peroxides (LPOs) accumulation and triggering ferroptosis of 4T1 cells. Meanwhile, IMD-0354-mediated Gln metabolic intervention is proven to inhibit glutathione (GSH) synthesis and activate lipophagy, thereby increasing free fatty acids (FFA) levels as an essential "fuel" for lipid peroxidation and overcoming a key limitation in ferroptosis efficacy. Additionally, Gln metabolism inhibition attenuates immunosuppressive M2 macrophage polarization, ultimately boosting antitumor immunity. Thus, MICLM effectively induces ferroptosis and remodels the tumor immune microenvironment via amino acid metabolic intervention, offering a promising strategy for ferroptosis-based therapy.