医学
急性肾损伤
表皮生长因子受体
肾
肾干细胞
肾功能
酪氨酸激酶
糖尿病肾病
表皮生长因子
肾病
癌症研究
内科学
内分泌学
受体
生物
糖尿病
干细胞
细胞生物学
祖细胞
作者
Jinhua Tang,Na Liu,Songlin Zhuang
摘要
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of EGFR by its exogenous ligands, like EGF, can enhance recovery of renal function and structure following acute kidney injury. However, recent studies indicated that EGFR activation also contributes to development and progression of renal diseases in animal models of obstructive nephropathy, diabetic nephropathy, hypertensive nephropathy, and glomerulonephritis through mechanisms involved in activation of renal interstitial fibroblasts, induction of tubular atrophy, overproduction of inflammatory factors, and/or promotion of glomerular and vascular injury. This review highlights the actions and mechanisms of EGFR in a variety of acute and chronic kidney injuries.
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