Could fecal calprotectin enter mainstream use for diagnosing and monitoring inflammatory bowel disease?

The authors found that the overall accuracy for differentiating IBD from IBS or other types of colitis was 94% and 91% respectively for Quantum Blue (cutoff, 50 g/g); 92% and 89% for EliA TM (cutoff, 50 g/g); and 82% and 76% for RIDAS-CREEN (cutoff, 50 g/g). The Quantum Blue Calprotectin and EliA TM Calprotectin results were significantly correlated with the CDAI (Spearman's rank correlation coefficient r=0.66 and 0.49 respectively) in patients with CD. EliA TM Calprotectin was significantly correlated with the Mayo score (r=0.70) in UC patients. Thus, the authors concluded that fecal calprotectin levels were useful in identifying IBD. Overall, these three fecal calprotectin kits were comparable in accuracy.