脊髓损伤
嗅鞘神经胶质
神经科学
移植
医学
脊髓
祖细胞
轴突
神经干细胞
神经保护
细胞疗法
少突胶质细胞
间充质干细胞
髓鞘
再生(生物学)
干细胞
生物
中枢神经系统
病理
外科
细胞生物学
嗅球
作者
Peggy Assinck,Greg J. Duncan,Brett J. Hilton,Jason R. Plemel,Wolfram Tetzlaff
摘要
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently, there is no effective treatment for the injured spinal cord. The transplantation of Schwann cells, neural stem cells or progenitor cells, olfactory ensheathing cells, oligodendrocyte precursor cells and mesenchymal stem cells has been investigated as potential therapies for spinal cord injury. However, little is known about the mechanisms through which these individual cell types promote repair and functional improvements. The five most commonly proposed mechanisms include neuroprotection, immunomodulation, axon regeneration, neuronal relay formation and myelin regeneration. A better understanding of the mechanisms whereby these cells promote functional improvements, as well as an appreciation of the obstacles in implementing these therapies and effectively modeling spinal cord injury, will be important to make cell transplantation a viable clinical option and may lead to the development of more targeted therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI