伏隔核
海马体
神经科学
单胺类神经递质
甲基苯丙胺
神经毒性
空间学习
胶质纤维酸性蛋白
海马结构
心理学
星形胶质增生
莫里斯水上航行任务
化学
多巴胺
血清素
内分泌学
内科学
医学
中枢神经系统
毒性
免疫组织化学
受体
作者
Arnold Gutierrez,Sarah A. Jablonski,Robyn M. Amos‐Kroohs,Anna C. Barnes,Michael T. Williams
标识
DOI:10.1021/acschemneuro.6b00419
摘要
Severe stress potentiates methamphetamine (MA) neurotoxicity. However, whether moderate stress increases or decreases the neurotoxic effects of MA is unknown. We assessed the effects of MA (4 × 10 mg/kg at 2 h intervals) in combination with prior barren-cage housing in adult male Sprague–Dawley rats on monoamines and glial fibrillary acid protein (GFAP) in one cohort and spatial learning and memory in the Morris water maze in another cohort. MA reduced dopamine (DA) and serotonin (5-HT) in the neostriatum and nucleus accumbens, 5-HT in the hippocampus, and increased GFAP in neostriatum and nucleus accumbens compared with saline controls. In neostriatum, barren-cage housing protected against MA-induced increases in GFAP, but it did not prevent DA and 5-HT reductions, although it did increase hippocampal norepinephrine. MA impaired spatial learning during acquisition, reversal, and shift phases and impaired reference memory on reversal and shift probe trials. Barren-cage housing enhanced performance during acquisition but not during reversal or shift or on probe trials. The data indicate that prior barren-cage housing moderates MA-induced neostriatal astrogliosis and initial spatial learning, but has no protective effect when the platform is smaller and relocated and therefore requires cognitive flexibility in relearning.
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